| Gene Information | |
|---|---|
| Gene Name | MST1R |
| Organism | Homo sapiens (Human) |
| Gene Length | 1400 |
| Protein Names | Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] |
| Target Name | macrophage-stimulating protein receptor |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000164078 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q04912 |
| Gene Card | MST1R |
| Uniprot ID | Q04912 |
| Pfam | PF07714; PF01403; PF01833 |
| In ASD | no |
| Allosteric Prediction | yes (0.841357847) |
| Ortholog in Animals | Alpaca_ MST1R ( ortholog_one2one ) Dog_ MST1R ( ortholog_one2one ) GuineaPig_ MST1R ( ortholog_one2one ) Macaque_ MST1R ( ortholog_one2one ) Mouse_ Mst1r ( ortholog_one2one ) Pig_ MST1R ( ortholog_one2one ) Rat_ Mst1r ( ortholog_one2one ) Rabbit_ MST1R ( ortholog_one2one ) |
| Ohnologs | MET |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | gall.bladder, zone.of.skin, small.intestine, esophagus.mucosa, lower.leg.skin, lung, small.intestine.Peyers.patch, stomach, suprapubic.skin, testis, transverse.colon, vagina |
| Tissue Specificity | Expressed in colon, skin, lung and bone marrow. {ECO:0000269|PubMed:8062829}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 3PLS (X-ray 2.24A ) 4FWW (X-ray 1.85A ) 4QT8 (X-ray 3.00A ) |
| DBSNP | rs35887539 rs55908300 rs55633379 rs200046052 rs2230593 rs200757776 rs35924402 rs2230591 rs2230592 rs34564898 rs34350470 rs2230590 rs35986685 rs201024956 rs56091918 rs773053723 rs7433231 rs528985327 rs1062633 rs56330223 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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