Gene Information
Gene NameSPTBN4
OrganismHomo sapiens (Human)
Gene Length2564
Protein NamesSpectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000160460 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ9H254
Gene CardSPTBN4
Uniprot IDQ9H254
PfamPF00307; PF15410; PF00435
In ASDno
Allosteric Predictionyes (0.311538377)
Ortholog in AnimalsAlpaca_ SPTBN4 ( ortholog_one2one )
Dog_ SPTBN4 ( ortholog_one2many )
GuineaPig_ SPTBN4 ( ortholog_one2one )
Mouse_ Sptbn4 ( ortholog_one2one )
Pig_ SPTBN4 ( ortholog_one2one )
Rat_ Sptbn4 ( ortholog_one2one )
Rabbit_ SPTBN4 ( ortholog_one2one )
OhnologsNA
ParalogsDSP, SPTBN5, ACTN4, MICAL2, DMD, SYNE3, GAS2L2, SPTBN2, FLNB, SPTAN1, SYNE2, PLEC, EPPK1, SYNE1, CLMN, DYTN, MICAL3, PKHD1, SMTNL2, DRP2, UTRN, PKHD1L1, ACTN2, ACTN3, MICAL1, SPTBN1, MACF1, ACTN1, DST, SPTB, GAS2L3, FLNC, FLNA, DTNA, SPTA1, DTNB
Tissuebrain, cerebellar.hemisphere, cerebellum
Tissue SpecificityExpressed in skeletal muscle at the sarcolemma and in the muscle capillaries (at protein level) (PubMed:28540413). Abundantly expressed in brain and pancreatic islets (PubMed:11086001). {ECO:0000269|PubMed:11086001, ECO:0000269|PubMed:28540413}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs814501 
Subcellular location [CC]Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}.
Mouse PG classificationNA
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