| Gene Information | |
|---|---|
| Gene Name | SF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 461 |
| Protein Names | Steroidogenic factor 1 (SF-1) (STF-1) (hSF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP) |
| Target Name | splicing factor 1 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000168066 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13285 |
| Gene Card | NR5A1 |
| Uniprot ID | Q13285 |
| Pfam | PF00104; PF00105 |
| In ASD | no |
| Allosteric Prediction | yes (0.116086857) |
| Ortholog in Animals | Alpaca_ SF1 ( ortholog_one2one ) Dog_ SF1 ( ortholog_one2one ) GuineaPig_ SF1 ( ortholog_one2one ) Macaque_ SF1 ( ortholog_one2one ) Mouse_ Sf1 ( ortholog_one2one ) Pig_ SF1 ( ortholog_one2one ) Rat_ Sf1 ( ortholog_one2one ) Rabbit_ SF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KHDRBS3, KHDRBS1, KHDRBS2, QKI |
| Tissue | NA |
| Tissue Specificity | High expressed in the adrenal cortex, the ovary, the testis, and the spleen (PubMed:9177385). {ECO:0000269|PubMed:9177385}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);0.046154(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1YOW (X-ray 3.00A ) 1ZDT (X-ray 2.10A ) 4QJR (X-ray 2.40A ) 4QK4 (X-ray 2.81A ) 7KHT (X-ray 2.50A ) |
| DBSNP | rs104894124 rs121918654 rs104894125 rs375469069 rs104894126 rs104894119 rs886039769 rs200163795 rs200749741 rs387906690 rs1110061 rs1253324106 rs201095702 rs780568525 rs104894118 rs121918655 rs104894120 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:11479297, ECO:0000269|PubMed:27490115}. |
| Mouse PG classification | NA |
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