| Gene Information | |
|---|---|
| Gene Name | SLC6A8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 635 |
| Protein Names | Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8) |
| Target Name | sodium- and chloride-dependent creatine transporter 1 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000130821 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P48029 |
| Gene Card | SLC6A8 |
| Uniprot ID | P48029 |
| Pfam | PF00209 |
| In ASD | no |
| Allosteric Prediction | yes (0.50531657) |
| Ortholog in Animals | Macaque_ SLC6A8 ( ortholog_one2many ) Mouse_ Slc6a8 ( ortholog_one2many ) Pig_ SLC6A8 ( ortholog_one2many ) Rat_ Slc6a8 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | SLC6A20, SLC6A9, SLC6A2, SLC6A18, SLC6A7, SLC6A4, SLC6A16, SLC6A5, SLC6A14, SLC6A6, SLC6A15, SLC6A13, SLC6A11, SLC6A19, SLC6A1, SLC6A17, SLC6A12, SLC6A3 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in skeletal muscle and kidney. Also found in brain, heart, colon, testis and prostate. {ECO:0000269|PubMed:7945388, ECO:0000269|PubMed:7953292}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1190261367 rs1233444890 rs122453115 rs122453117 rs642454 rs372601430 rs146985734 rs376937460 rs144678921 rs373953317 rs782433037 rs122453116 rs122453114 rs1557045267 rs80338740 rs122453118 rs782354054 rs199635059 rs372567920 rs397515559 rs145438966 rs201044530 rs146949376 rs368555229 rs781899045 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:22644605}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:12433955}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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