Gene Information
Gene NameSETD2
OrganismHomo sapiens (Human)
Gene Length2564
Protein NamesHistone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000181555 )
Evolutionary StageEukaryota
AlphaFoldDBQ9BYW2
Gene CardSETD2
Uniprot IDQ9BYW2
PfamPF17907; PF00856; PF08236; PF00397
In ASDno
Allosteric Predictionno (-0.476994939)
Ortholog in AnimalsAlpaca_ SETD2 ( ortholog_one2one )
Dog_ SETD2 ( ortholog_one2one )
GuineaPig_ SETD2 ( ortholog_one2one )
Macaque_ SETD2 ( ortholog_one2one )
Mouse_ Setd2 ( ortholog_one2one )
Pig_ SETD2 ( ortholog_one2one )
Rat_ Setd2 ( ortholog_one2one )
OhnologsNA
ParalogsKMT2B, ASH1L, NSD3, EHMT2, SUV39H1, EZH1, KMT2A, SETBP1, SETD1B, SETD1A, SUV39H2, EHMT1, KMT2D, NSD2, SETDB2, EZH2, KMT2C, NSD1, SETDB1
TissueNA
Tissue SpecificityUbiquitously expressed. {ECO:0000269|PubMed:11461154}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.02963(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2A7O  (NMR  2MDC  (NMR  2MDI  (NMR  2MDJ  (NMR  4FMU  (X-ray  2.10A  4H12  (X-ray  1.99A  5JJY  (X-ray  2.05A  5JLB  (X-ray  1.50A  5JLE  (X-ray  2.40A  5LSS  (X-ray  1.79A  5LSX  (X-ray  2.90A  5LSY  (X-ray  1.62A  5LSZ  (X-ray  1.62A  5LT6  (X-ray  2.05A  5LT7  (X-ray  1.51A  5LT8  (X-ray  1.57A  5V21  (X-ray  2.42A  5V22  (X-ray  2.40A  6J9J  (X-ray  1.78A  6VDB  (X-ray  2.30A  7EA8  (EM  3.10A  7EVR  (X-ray  1.80A  7EVS  (X-ray  1.60A  7LZB  (X-ray  2.28A  7LZD  (X-ray  1.80A  7LZF  (X-ray  2.47A  7TY2  (X-ray  2.44A  7TY3  (X-ray  2.30A 
DBSNP rs780963440  rs186148199  rs757781388  rs188887061  rs9311404  rs1169288572  rs58906143  rs540476365  rs754921650  rs1478147351  rs869025570  rs11721074  rs4082155 
Subcellular location [CC]Nucleus {ECO:0000250|UniProtKB:E9Q5F9}. Chromosome {ECO:0000250|UniProtKB:E9Q5F9}.
Mouse PG classificationNA
click here to return to the previous page