| Gene Information | |
|---|---|
| Gene Name | SMC1L2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1235 |
| Protein Names | Structural maintenance of chromosomes protein 1B (SMC protein 1B) (SMC-1-beta) (SMC-1B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8NDV3 |
| Gene Card | SMC1B |
| Uniprot ID | Q8NDV3 |
| Pfam | PF06470; PF02463 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001958(Rat);0.092308(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs136603 rs9614653 rs16993928 rs5764698 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q920F6}. Chromosome {ECO:0000250|UniProtKB:Q920F6}. Chromosome, centromere {ECO:0000250|UniProtKB:Q920F6}. Note=Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation (By similarity). {ECO:0000250|UniProtKB:Q920F6}. |
| Mouse PG classification | NA |
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