Gene Information
Gene NameELOVL2
OrganismHomo sapiens (Human)
Gene Length299
Protein NamesElongation of very long chain fatty acids protein 5 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL5) (ELOVL fatty acid elongase 5) (ELOVL FA elongase 5) (Fatty acid elongase 1) (hELO1) (Very long chain 3-ketoacyl-CoA synthase 5) (Very long chain 3-oxoacyl-CoA synthase 5)
Target Nameelongation of very long chain fatty acids protein 2
Target TypeNA
Gene Age1714 ( ENSG00000197977 )
Evolutionary StageEukaryota
AlphaFoldDBQ9NYP7
Gene CardELOVL5
Uniprot IDQ9NYP7
PfamPF01151
In ASDno
Allosteric Predictionno (-1.074585979)
Ortholog in AnimalsAlpaca_ ELOVL2 ( ortholog_one2one )
Dog_ ELOVL2 ( ortholog_one2one )
GuineaPig_ ELOVL2 ( ortholog_one2one )
Macaque_ ELOVL2 ( ortholog_one2one )
Mouse_ Elovl2 ( ortholog_one2one )
Pig_ ELOVL2 ( ortholog_one2one )
Rat_ Elovl2 ( ortholog_one2one )
Rabbit_ ELOVL2 ( ortholog_one2one )
OhnologsELOVL5, ELOVL1
ParalogsELOVL5, ELOVL4, ELOVL1, ELOVL7, ELOVL3, ELOVL6
Tissuecerebral.cortex, liver, placenta, testis, brain
Tissue SpecificityUbiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum. {ECO:0000269|PubMed:10970790, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:25065913}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs587777671  rs587777670 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03205, ECO:0000269|PubMed:20937905};
Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03205}. Cell projection, dendrite {ECO:0000255|HAMAP-Rule:MF_03205, ECO:0000269|PubMed:25065913}. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. {ECO:0000255|HAMAP-Rule:MF_03205, ECO:0000269|PubMed:25065913}.
Mouse PG classificationNA
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