| Gene Information | |
|---|---|
| Gene Name | SIGLEC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1709 |
| Protein Names | Sialoadhesin (Sialic acid-binding Ig-like lectin 1) (Siglec-1) (CD antigen CD169) |
| Target Name | sialoadhesin |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000088827 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BZZ2 |
| Gene Card | SIGLEC1 |
| Uniprot ID | Q9BZZ2 |
| Pfam | PF08205; PF07679; PF13895; PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.540416135) |
| Ortholog in Animals | Alpaca_ SIGLEC1 ( ortholog_one2one ) Dog_ SIGLEC1 ( ortholog_one2one ) GuineaPig_ SIGLEC1 ( ortholog_one2one ) Macaque_ SIGLEC1 ( ortholog_one2one ) Mouse_ Siglec1 ( ortholog_one2one ) Pig_ SIGLEC1 ( ortholog_one2one ) Rat_ Siglec1 ( ortholog_one2one ) Rabbit_ SIGLEC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MAG, SIGLECL1, CD22, SIGLEC15, SIGLEC5, SIGLEC7, SIGLEC11, SIGLEC8, CD33, SIGLEC9, SIGLEC12, SIGLEC16, SIGLEC10, SIGLEC14, SIGLEC6, TMEM25 |
| Tissue | NA |
| Tissue Specificity | Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35953127 rs6037651 rs625372 rs34924243 rs709012 rs3746638 rs3746636 rs16988873 rs2853217 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted. |
| Mouse PG classification | NA |
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