| Gene Information | |
|---|---|
| Gene Name | SPDEF |
| Organism | Homo sapiens (Human) |
| Gene Length | 335 |
| Protein Names | SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000124664 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95238 |
| Gene Card | SPDEF |
| Uniprot ID | O95238 |
| Pfam | PF00178; PF02198 |
| In ASD | no |
| Allosteric Prediction | no (-0.458200185) |
| Ortholog in Animals | Alpaca_ SPDEF ( ortholog_one2one ) Dog_ SPDEF ( ortholog_one2one ) GuineaPig_ SPDEF ( ortholog_one2one ) Macaque_ SPDEF ( ortholog_one2one ) Mouse_ Spdef ( ortholog_one2one ) Pig_ SPDEF ( ortholog_one2one ) Rat_ Spdef ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ELK1, ETV6, ERG, ERF, ETV4, ETV7, ELF4, ELF3, EHF, ETV2, ETV3L, ETS2, FLI1, GABPA, ETV5, ETV1, ELF5, ETV3, ELK3, ETS1, ELF2, SPI1, ELK4, ELF1, SPIB, FEV, SPIC, ERFL |
| Tissue | prostate, parotid.gland, submandibular.gland |
| Tissue Specificity | Expressed in a very restricted set of primarily hormone-regulated epithelial tissues with particularly high expression in the prostate gland. Significantly lower expression is seen in other hormone regulated tissues such as mammary gland, salivary gland, and ovary. Expressed in prostate carcinoma cells. {ECO:0000269|PubMed:10625666}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1YO5 (X-ray 2.00A ) 2DKX (NMR - ) |
| DBSNP | rs2233639 |
| Subcellular location [CC] | Nucleus {ECO:0000305}. |
| Mouse PG classification | NA |
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