| Gene Information | |
|---|---|
| Gene Name | SERPINI1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 410 |
| Protein Names | Neuroserpin (Peptidase inhibitor 12) (PI-12) (Serpin I1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000163536 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q99574 |
| Gene Card | SERPINI1 |
| Uniprot ID | Q99574 |
| Pfam | PF00079 |
| In ASD | no |
| Allosteric Prediction | no (-0.286442203) |
| Ortholog in Animals | Alpaca_ SERPINI1 ( ortholog_one2one ) Dog_ SERPINI1 ( ortholog_one2one ) GuineaPig_ SERPINI1 ( ortholog_one2one ) Macaque_ SERPINI1 ( ortholog_one2one ) Mouse_ Serpini1 ( ortholog_one2one ) Pig_ SERPINI1 ( ortholog_one2one ) Rat_ Serpini1 ( ortholog_one2one ) Rabbit_ SERPINI1 ( ortholog_one2one ) |
| Ohnologs | SERPINE1, SERPINC1, SERPINE2 |
| Paralogs | SERPING1, SERPINB7, SERPINF1, AGT, SERPIND1, SERPINA7, SERPINB8, SERPINA6, SERPINI2, HMSD, SERPINB6, SERPINC1, SERPINB1, SERPINA10, SERPINH1, SERPINB13, SERPINA3, SERPINA5, SERPINA9, SERPINA12, SERPINE1, SERPINF2, SERPINA4, SERPINB11, SERPINB5, SERPINB12, SERPINB9, SERPINE3, SERPINB4, SERPINB3, SERPINE2, SERPINA1, SERPINA2, SERPINB10, SERPINA11, SERPINB2 |
| Tissue | NA |
| Tissue Specificity | Detected in brain cortex and hippocampus pyramidal neurons (at protein level) (PubMed:17040209). Predominantly expressed in the brain (PubMed:9070919). {ECO:0000269|PubMed:17040209, ECO:0000269|PubMed:9070919}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3F02 (X-ray 1.80A ) 3F5N (X-ray 3.15A ) 3FGQ (X-ray 2.09A ) |
| DBSNP | rs121909051 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:17040209}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000305|PubMed:17040209}. Perikaryon {ECO:0000269|PubMed:17040209}. |
| Mouse PG classification | LPG |
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