| Gene Information | |
|---|---|
| Gene Name | KCNJ4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 445 |
| Protein Names | Inward rectifier potassium channel 4 (HIRK2) (HRK1) (Hippocampal inward rectifier) (HIR) (Inward rectifier K(+) channel Kir2.3) (IRK-3) (Potassium channel, inwardly rectifying subfamily J member 4) |
| Target Name | inward rectifier potassium channel |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000168135 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P48050 |
| Gene Card | KCNJ4 |
| Uniprot ID | P48050 |
| Pfam | PF01007; PF17655 |
| In ASD | no |
| Allosteric Prediction | yes (0.861747578) |
| Ortholog in Animals | Alpaca_ KCNJ4 ( ortholog_one2one ) GuineaPig_ KCNJ4 ( ortholog_one2one ) Macaque_ KCNJ4 ( ortholog_one2one ) Mouse_ Kcnj4 ( ortholog_one2one ) Pig_ KCNJ4 ( ortholog_one2one ) Rat_ Kcnj4 ( ortholog_one2one ) Rabbit_ KCNJ4 ( ortholog_one2one ) |
| Ohnologs | KCNJ5, KCNJ2, KCNJ14, KCNJ12 |
| Paralogs | KCNJ9, KCNJ3, KCNJ5, KCNJ6, KCNJ11, KCNJ15, KCNJ10, KCNJ13, KCNJ8, KCNJ1, KCNJ18, KCNJ12, KCNJ14, KCNJ2, KCNJ16 |
| Tissue | brain, heart, cerebral.cortex, nucleus.accumbens |
| Tissue Specificity | Heart, skeletal muscle, and several different brain regions including the hippocampus. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3GJ9 (X-ray 2.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization. {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |