| Gene Information | |
|---|---|
| Gene Name | CLEC2D |
| Organism | Homo sapiens (Human) |
| Gene Length | 191 |
| Protein Names | C-type lectin domain family 2 member D (Lectin-like NK cell receptor) (Lectin-like transcript 1) (LLT-1) (Osteoclast inhibitory lectin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000069493 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UHP7 |
| Gene Card | CLEC2D |
| Uniprot ID | Q9UHP7 |
| Pfam | PF00059 |
| In ASD | no |
| Allosteric Prediction | no (-1.397628975) |
| Ortholog in Animals | Alpaca_ CLEC2D ( ortholog_one2one ) Macaque_ CLEC2D ( ortholog_one2one ) Mouse_ Clec2e ( ortholog_one2many ) Mouse_ Clec2d ( ortholog_one2many ) Mouse_ Clec2h ( ortholog_one2many ) Mouse_ Clec2i ( ortholog_one2many ) Mouse_ Clec2g ( ortholog_one2many ) Rat_ Clec2d2 ( ortholog_one2many ) Rat_ Clec2e ( ortholog_one2many ) Rat_ AABR07062138.2 ( ortholog_one2many ) Rat_ Clec2d ( ortholog_one2many ) Rat_ Clec2h ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | CD69, CLEC12A, KLRC3, KLRC2, CLEC12B, OLR1, KLRG2, CLEC2A, KLRF1, CLEC1A, KLRF2, KLRD1, CLEC2B, KLRC1, CLEC2L, KLRG1, CLEC9A, CLEC1B, KLRC4, KLRK1, CLEC5A, CLEC7A, KLRB1 |
| Tissue | appendix, adipose.tissue, spleen |
| Tissue Specificity | Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells. {ECO:0000269|PubMed:10541800, ECO:0000269|PubMed:20843815}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4QKG (X-ray 1.95A ) 4QKH (X-ray 1.80A ) 4QKI (X-ray 1.80A ) 4QKJ (X-ray 2.75A ) 4WCO (X-ray 2.46A ) 5MGT (X-ray 1.90A ) |
| DBSNP | rs16914640 rs3764022 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15104121, ECO:0000269|PubMed:20843815, ECO:0000305|PubMed:16339513}; Single-pass type II membrane protein {ECO:0000255}.; [Isoform 2]: Endoplasmic reticulum {ECO:0000269|PubMed:20843815}.; [Isoform 4]: Endoplasmic reticulum {ECO:0000269|PubMed:20843815}. |
| Mouse PG classification | NA |
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