| Gene Information | |
|---|---|
| Gene Name | SERPINB6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 376 |
| Protein Names | Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor) |
| Target Name | serpin b6 |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000124570 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P35237 |
| Gene Card | SERPINB6 |
| Uniprot ID | P35237 |
| Pfam | PF00079 |
| In ASD | no |
| Allosteric Prediction | yes (0.294464058) |
| Ortholog in Animals | Alpaca_ SERPINB6 ( ortholog_one2one ) GuineaPig_ SERPINB6 ( ortholog_one2one ) Macaque_ SERPINB6 ( ortholog_one2one ) Mouse_ Serpinb6a ( ortholog_one2many ) Mouse_ Serpinb6c ( ortholog_one2many ) Mouse_ Serpinb6e ( ortholog_one2many ) Mouse_ Serpinb6b ( ortholog_one2many ) Mouse_ Serpinb6d ( ortholog_one2many ) Rat_ RGD1564786 ( ortholog_one2many ) Rat_ Serpinb6b ( ortholog_one2many ) Rat_ Serpinb6a ( ortholog_one2many ) Rat_ Serpinb6e ( ortholog_one2many ) |
| Ohnologs | SERPINB12, SERPINB5 |
| Paralogs | SERPING1, SERPINB7, SERPINF1, SERPINI1, AGT, SERPIND1, SERPINA7, SERPINB8, SERPINA6, SERPINI2, SERPINC1, SERPINB1, SERPINA10, SERPINH1, SERPINB13, SERPINA3, SERPINA5, SERPINA9, SERPINA12, SERPINE1, SERPINF2, SERPINA4, SERPINB11, SERPINB5, SERPINB12, SERPINB9, SERPINE3, SERPINB4, SERPINB3, SERPINE2, SERPINA1, SERPINA2, SERPINB10, SERPINA11, SERPINB2, HMSD |
| Tissue | NA |
| Tissue Specificity | Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. {ECO:0000269|PubMed:14670919, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2295769 rs2295766 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14670919, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8486644}. |
| Mouse PG classification | NA |
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