Gene Information
Gene NameSERPINB1
OrganismHomo sapiens (Human)
Gene Length379
Protein NamesLeukocyte elastase inhibitor (LEI) (Monocyte/neutrophil elastase inhibitor) (EI) (M/NEI) (Peptidase inhibitor 2) (PI-2) (Serpin B1)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000021355 )
Evolutionary StageCellular_organisms
AlphaFoldDBP30740
Gene CardSERPINB1
Uniprot IDP30740
PfamPF00079
In ASDno
Allosteric Predictionno (-0.462724703)
Ortholog in AnimalsAlpaca_ SERPINB1 ( ortholog_one2one )
Dog_ SERPINB1 ( ortholog_one2one )
GuineaPig_ SERPINB1 ( ortholog_one2one )
Macaque_ SERPINB1 ( ortholog_one2one )
Mouse_ Serpinb1a ( ortholog_one2many )
Mouse_ Serpinb1c ( ortholog_one2many )
Mouse_ Serpinb1b ( ortholog_one2many )
Pig_ SERPINB1 ( ortholog_one2one )
Rat_ Serpinb1a ( ortholog_one2many )
Rat_ Serpinb1b ( ortholog_one2many )
OhnologsSERPINB12, SERPINB5
ParalogsSERPING1, SERPINB7, SERPINF1, SERPINI1, AGT, SERPIND1, SERPINA7, SERPINB8, SERPINA6, SERPINI2, HMSD, SERPINB6, SERPINC1, SERPINA10, SERPINH1, SERPINB13, SERPINA3, SERPINA5, SERPINA9, SERPINA12, SERPINE1, SERPINF2, SERPINA4, SERPINB11, SERPINB5, SERPINB12, SERPINB9, SERPINE3, SERPINB4, SERPINB3, SERPINE2, SERPINA1, SERPINA2, SERPINB10, SERPINA11, SERPINB2
TissueNA
Tissue SpecificityIn human bone marrow, present in all CD45+ populations. Expression levels are highest in the neutrophil lineage, intermediate in monocytic, and lowest in lymphocytic lineage. Within the neutrophil lineage, expression is highest in promyelocytes. {ECO:0000269|PubMed:21248149}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4GA7  (X-ray  2.90A  ) 
DBSNP rs34825616 
Subcellular location [CC]Secreted {ECO:0000269|PubMed:26701651}. Cytoplasm {ECO:0000269|PubMed:23269243}. Cytolytic granule {ECO:0000269|PubMed:23269243}. Early endosome {ECO:0000269|PubMed:23269243}.
Mouse PG classificationNA
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