| Gene Information | |
|---|---|
| Gene Name | SPRY2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 315 |
| Protein Names | Protein sprouty homolog 2 (Spry-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000136158 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O43597 |
| Gene Card | SPRY2 |
| Uniprot ID | O43597 |
| Pfam | PF05210 |
| In ASD | no |
| Allosteric Prediction | yes (0.089819637) |
| Ortholog in Animals | Alpaca_ SPRY2 ( ortholog_one2one ) Dog_ SPRY2 ( ortholog_one2one ) GuineaPig_ SPRY2 ( ortholog_one2one ) Macaque_ SPRY2 ( ortholog_one2one ) Mouse_ Spry2 ( ortholog_one2one ) Pig_ SPRY2 ( ortholog_one2one ) Rat_ Spry2 ( ortholog_one2one ) Rabbit_ SPRY2 ( ortholog_one2one ) |
| Ohnologs | SPRY3, SPRY1, SPRY4 |
| Paralogs | SPRY3, SPRY1, SPRY4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.015385(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3BUM (X-ray 2.00A ) 3OB1 (X-ray 2.20A ) 5HKY (X-ray 1.80A ) 5HKZ (X-ray 1.80A ) 5HL0 (X-ray 2.20A ) |
| DBSNP | rs504122 rs869025336 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10887178}. Cell projection, ruffle membrane {ECO:0000269|PubMed:10887178}. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor). {ECO:0000269|PubMed:10887178}. |
| Mouse PG classification | LPG |
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