| Gene Information | |
|---|---|
| Gene Name | SERPINA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 423 |
| Protein Names | Alpha-1-antichymotrypsin (ACT) (Cell growth-inhibiting gene 24/25 protein) (Serpin A3) [Cleaved into: Alpha-1-antichymotrypsin His-Pro-less] |
| Target Name | alpha-1-antichymotrypsin |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000196136 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P01011 |
| Gene Card | SERPINA3 |
| Uniprot ID | P01011 |
| Pfam | PF00079 |
| In ASD | yes |
| Allosteric Prediction | yes (1.03730988) |
| Ortholog in Animals | Alpaca_ SERPINA3 ( ortholog_one2one ) Dog_ SERPINA3 ( ortholog_one2one ) GuineaPig_ SERPINA3 ( ortholog_one2one ) Macaque_ SERPINA3 ( ortholog_one2one ) Mouse_ Serpina3g ( ortholog_one2many ) Mouse_ Serpina3c ( ortholog_one2many ) Mouse_ Serpina3n ( ortholog_one2many ) Mouse_ Serpina3f ( ortholog_one2many ) Mouse_ Serpina3k ( ortholog_one2many ) Mouse_ Serpina3i ( ortholog_one2many ) Mouse_ Serpina3a ( ortholog_one2many ) Mouse_ Serpina3m ( ortholog_one2many ) Mouse_ Serpina3b ( ortholog_one2many ) Mouse_ Serpina3j ( ortholog_one2many ) Rat_ Serpina3c ( ortholog_one2many ) Rat_ RGD1565462 ( ortholog_one2many ) Rat_ Serpina3n ( ortholog_one2many ) Rat_ Serpina3m ( ortholog_one2many ) Rabbit_ SERPINA3 ( ortholog_one2one ) |
| Ohnologs | SERPIND1 |
| Paralogs | SERPING1, SERPINB7, SERPINF1, SERPINI1, AGT, SERPIND1, SERPINA7, SERPINB8, SERPINA6, SERPINI2, HMSD, SERPINB6, SERPINC1, SERPINB1, SERPINA10, SERPINH1, SERPINB13, SERPINA5, SERPINA9, SERPINA12, SERPINE1, SERPINF2, SERPINA4, SERPINB11, SERPINB5, SERPINB12, SERPINB9, SERPINE3, SERPINB4, SERPINB3, SERPINE2, SERPINA1, SERPINA2, SERPINB10, SERPINA11, SERPINB2 |
| Tissue | liver, pancreas |
| Tissue Specificity | Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains. {ECO:0000269|PubMed:3257719, ECO:0000269|PubMed:9880565}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1AS4 (X-ray 2.10A ) 1QMN (X-ray 2.27A ) 2ACH (X-ray 2.70A ) 3CAA (X-ray 2.40A ) 3DLW (X-ray 2.70A ) 4CAA (X-ray 2.90A ) 6HGE (X-ray 2.80A ) |
| DBSNP | rs4934 rs1800463 rs17473 rs17853314 rs755521612 rs10956 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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