| Gene Information | |
|---|---|
| Gene Name | SEPT8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 483 |
| Protein Names | Septin-8 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q92599 |
| Gene Card | SEPTIN8 |
| Uniprot ID | Q92599 |
| Pfam | PF00735 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary. {ECO:0000269|PubMed:12023038, ECO:0000269|PubMed:12909369, ECO:0000269|PubMed:15116257, ECO:0000269|PubMed:15915442, ECO:0000269|PubMed:27084579}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6UPR (X-ray 2.30A ) 6WSM (X-ray 2.45A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:B0BNF1}. Cytoplasm, cytoskeleton {ECO:0000250}. Synapse {ECO:0000250|UniProtKB:B0BNF1}. Cell projection, axon {ECO:0000250|UniProtKB:B0BNF1}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:B0BNF1}. Presynapse {ECO:0000250|UniProtKB:B0BNF1}. Note=Expressed in axons of immature neurons, localizes to synapses in mature neurons (By similarity). In platelets, found in areas surrounding alpha-granules (PubMed:15116257). {ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}. |
| Mouse PG classification | NA |
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