| Gene Information | |
|---|---|
| Gene Name | SLC5A5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 643 |
| Protein Names | Sodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Natrium iodide transporter) (Sodium-iodide symporter) (Na(+)/I(-) symporter) (Solute carrier family 5 member 5) |
| Target Name | sodium/iodide cotransporter |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000105641 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q92911 |
| Gene Card | SLC5A5 |
| Uniprot ID | Q92911 |
| Pfam | PF00474 |
| In ASD | no |
| Allosteric Prediction | yes (0.197554047) |
| Ortholog in Animals | Alpaca_ SLC5A5 ( ortholog_one2one ) Dog_ SLC5A5 ( ortholog_one2one ) GuineaPig_ SLC5A5 ( ortholog_one2one ) Macaque_ SLC5A5 ( ortholog_one2one ) Mouse_ Slc5a5 ( ortholog_one2one ) Pig_ SLC5A5 ( ortholog_one2one ) Rat_ Slc5a5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLC5A11, SLC5A8, SLC5A1, SLC5A6, SLC5A9, SLC5A3, SLC5A10, SLC5A4, SLC5A2, SLC5A12, SLC5A7 |
| Tissue | salivary.gland, stomach, medulla.oblongata, parotid.gland, submandibular.gland |
| Tissue Specificity | Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors. {ECO:0000269|PubMed:8806637, ECO:0000269|PubMed:9329364}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs121909178 rs121909176 rs8108188 rs121909174 rs121909180 rs121909179 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18372236, ECO:0000269|PubMed:18708479, ECO:0000269|PubMed:20797386, ECO:0000269|PubMed:31310151}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:18372236, ECO:0000269|PubMed:31310151}. |
| Mouse PG classification | NA |
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