| Gene Information | |
|---|---|
| Gene Name | SENP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 574 |
| Protein Names | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000161956 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H4L4 |
| Gene Card | SENP3 |
| Uniprot ID | Q9H4L4 |
| Pfam | PF02902; PF19722 |
| In ASD | no |
| Allosteric Prediction | no (-0.555987835) |
| Ortholog in Animals | Alpaca_ SENP3 ( ortholog_one2one ) Dog_ SENP3 ( ortholog_one2one ) GuineaPig_ SENP3 ( ortholog_one2one ) Macaque_ SENP3 ( ortholog_one2one ) Mouse_ Senp3 ( ortholog_one2one ) Pig_ SENP3 ( ortholog_one2one ) Rat_ Senp3 ( ortholog_one2one ) Rabbit_ SENP3 ( ortholog_one2one ) |
| Ohnologs | SENP5 |
| Paralogs | SENP5, SENP2, SENP1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.010526(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs9972914 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:19680224}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224}. Cytoplasm {ECO:0000250|UniProtKB:Q9EP97}. Note=Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (PubMed:19680224). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). {ECO:0000250|UniProtKB:Q9EP97, ECO:0000269|PubMed:19680224}. |
| Mouse PG classification | NA |
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