| Gene Information | |
|---|---|
| Gene Name | SEMA7A |
| Organism | Homo sapiens (Human) |
| Gene Length | 666 |
| Protein Names | Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000138623 ) 3 ( ENSG00000288455 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O75326 |
| Gene Card | SEMA7A |
| Uniprot ID | O75326 |
| Pfam | PF13895; PF01437; PF01403 |
| In ASD | no |
| Allosteric Prediction | no (-0.852972079) |
| Ortholog in Animals | Alpaca_ SEMA7A ( ortholog_one2one ) Dog_ SEMA7A ( ortholog_one2one ) GuineaPig_ SEMA7A ( ortholog_one2one ) Macaque_ SEMA7A ( ortholog_one2one ) Mouse_ Sema7a ( ortholog_one2one ) Pig_ SEMA7A ( ortholog_one2one ) Rat_ Sema7a ( ortholog_one2one ) |
| Ohnologs | SEMA4B, SEMA4A |
| Paralogs | SEMA4D, SEMA6D, SEMA3A, SEMA3F, SEMA6C, SEMA3E, SEMA3D, SEMA6B, SEMA4B, SEMA4F, SEMA3B, SEMA4G, SEMA3C, SEMA5A, SEMA4A, SEMA5B, SEMA3G, SEMA4C, SEMA6A |
| Tissue | NA |
| Tissue Specificity | Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney. {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3NVQ (X-ray 2.40A ) |
| DBSNP | rs16968733 rs55637216 rs56367230 rs387907241 rs56204206 rs56001514 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}; Extracellular side {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes. |
| Mouse PG classification | NA |
| click here to return to the previous page | |