| Gene Information | |
|---|---|
| Gene Name | SEMA4D |
| Organism | Homo sapiens (Human) |
| Gene Length | 862 |
| Protein Names | Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) |
| Target Name | semaphorin-4d |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000187764 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q92854 |
| Gene Card | SEMA4D |
| Uniprot ID | Q92854 |
| Pfam | PF00047; PF01437; PF01403 |
| In ASD | no |
| Allosteric Prediction | no (-0.091090938) |
| Ortholog in Animals | Alpaca_ SEMA4D ( ortholog_one2one ) Dog_ SEMA4D ( ortholog_one2one ) GuineaPig_ SEMA4D ( ortholog_one2one ) Macaque_ SEMA4D ( ortholog_one2one ) Mouse_ Sema4d ( ortholog_one2one ) Pig_ SEMA4D ( ortholog_one2one ) Rat_ Sema4d ( ortholog_one2one ) Rabbit_ SEMA4D ( ortholog_one2one ) |
| Ohnologs | SEMA4G, SEMA6D, SEMA6B, SEMA4B, SEMA4F, SEMA6C, SEMA4C, SEMA4A |
| Paralogs | SEMA6D, SEMA3A, SEMA3F, SEMA6C, SEMA3E, SEMA3D, SEMA6B, SEMA4B, SEMA4F, SEMA3B, SEMA4G, SEMA3C, SEMA5A, SEMA4A, SEMA5B, SEMA7A, SEMA3G, SEMA4C, SEMA6A |
| Tissue | NA |
| Tissue Specificity | Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. {ECO:0000269|PubMed:8876214}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1OLZ (X-ray 2.00A ) 3OL2 (X-ray 2.99A ) |
| DBSNP | rs13284404 rs11526468 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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