Gene Information
Gene NameIGHM
OrganismHomo sapiens (Human)
Gene Length453
Protein NamesImmunoglobulin heavy constant mu (Ig mu chain C region) (Ig mu chain C region BOT) (Ig mu chain C region GAL) (Ig mu chain C region OU)
Target Nameig mu chain c region
Target TypeNA
Gene Age544 ( ENSG00000211899 )
Evolutionary StageNA
AlphaFoldDBP01871
Gene CardIGHM
Uniprot IDP01871
PfamPF07654
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsMacaque_ IGHM ( ortholog_one2one )
Mouse_ Ighm ( ortholog_one2one )
Pig_ IGHM ( ortholog_one2one )
Rat_ Ighm ( ortholog_one2one )
Rabbit_ IGHM ( ortholog_one2one )
OhnologsNA
ParalogsTRDC, IGHV4OR15-8, IGHV4-4, IGHV4-61, IGHV4-59, IGHV4-39, IGHV4-31, IGHV4-28, IGHV4-34, IGHV6-1, IGHV2-5, IGHV2OR16-5, IGHV2-26, IGHV2-70D, IGHV2-70, IGKC, IGHV5-51, IGHV5-10-1, IGHV1-69-2, IGHV1-24, IGHV1-3, IGHV1-58, IGHV1-45, IGHV1-18, IGHV1-69, IGHV1-69D, IGHV1-2, IGHV1OR15-1, IGHV1-46, IGHV1OR15-9, IGHV1OR21-1, IGHV3OR16-9, IGHV3OR16-8, IGHV3OR16-17, IGHV3-35, IGHV3-16, IGLL1, IGLC7, IGLC3, IGLC2, IGLC1, IGLL5, IGHV7-81, IGHV7-4-1, IGHG3, IGHG1, IGHG2, IGHG4, IGHE, IGHV3-13, IGHV3OR16-10, IGHV3-48, IGHV3-21, IGHV3-11, IGHV3-43, IGHV3-20, IGHV3-74, IGHV3OR16-13, IGHV3-73, IGHV3-72, IGHV3OR15-7, IGHV3-15, IGHV3-49, IGHV3-30, IGHV3-33, IGHV3-7, IGHV8-51-1, IGHV3-64D, IGHV3-64, IGHV3-23, IGHV3-66, IGHV3-53, IGHV3-38, IGHV3OR16-12, IGHA1, IGHA2, IGHD
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1HEZ  (X-ray  2.70A  )  2AGJ  (X-ray  2.60A  )  2RCJ  (X-ray  -  )  6KXS  (EM  3.40A  )  7K0C  (EM  3.30A  ) 
DBSNP rs12365 
Subcellular location [CC][Isoform 1]: Secreted. Note=During differentiation, B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM.;
[Isoform 2]: Cell membrane;
Single-pass type I membrane protein.
Mouse PG classificationNA
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