| Gene Information | |
|---|---|
| Gene Name | PRKAR2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 418 |
| Protein Names | cAMP-dependent protein kinase type II-beta regulatory subunit |
| Target Name | camp-dependent protein kinase type ii-beta regulatory subunit |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000005249 ) 3 ( ENSG00000284096 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P31323 |
| Gene Card | PRKAR2B |
| Uniprot ID | P31323 |
| Pfam | PF00027; PF02197 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999703131) |
| Ortholog in Animals | Alpaca_ PRKAR2B ( ortholog_one2one ) Dog_ PRKAR2B ( ortholog_one2one ) GuineaPig_ PRKAR2B ( ortholog_one2one ) Macaque_ PRKAR2B ( ortholog_one2one ) Mouse_ Prkar2b ( ortholog_one2one ) Pig_ PRKAR2B ( ortholog_one2one ) Rat_ Prkar2b ( ortholog_one2one ) Rabbit_ PRKAR2B ( ortholog_one2one ) |
| Ohnologs | PRKAR2A |
| Paralogs | PRKAR2A, CNBD1, PRKAR1A, PRKAR1B |
| Tissue | NA |
| Tissue Specificity | Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.027741(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs3729881 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane. |
| Mouse PG classification | NA |
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