| Gene Information | |
|---|---|
| Gene Name | SELP |
| Organism | Homo sapiens (Human) |
| Gene Length | 381 |
| Protein Names | Selenoprotein P (SeP) |
| Target Name | p-selectin |
| Target Type | Successful target |
| Gene Age | 987 ( ENSG00000174175 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | NA |
| Gene Card | SELENOP |
| Uniprot ID | P49908 |
| Pfam | PF04593; PF04592 |
| In ASD | no |
| Allosteric Prediction | yes (0.999830018) |
| Ortholog in Animals | Alpaca_ SELP ( ortholog_one2one ) Dog_ SELP ( ortholog_one2one ) GuineaPig_ SELP ( ortholog_one2one ) Macaque_ SELP ( ortholog_one2one ) Mouse_ Selp ( ortholog_one2one ) Pig_ SELP ( ortholog_one2one ) Rat_ Selp ( ortholog_one2one ) Rabbit_ SELP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CR1L, SUSD3, F13B, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SELE, SRPX, SVEP1, SEZ6, C8A, CD55, CSMD2, PAPPA2, SUSD6, C4BPA, C9, CR1, PAPPA, SELL, CFB, CD46, C4BPB, CR2, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, SRPX2, C8B, PRF1, SUSD4, C6, C2 |
| Tissue | NA |
| Tissue Specificity | Made in the liver and heart and secreted into the plasma. It is also found in the kidney. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs28919895 rs3877899 rs28919923 rs28919925 rs28919926 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:8142465}. Note=Passes from plasma into the glomerular filtrate where it is removed by endocytosis mediated by LRP2 in the proximal tubule epithelium. {ECO:0000250|UniProtKB:P70274}. |
| Mouse PG classification | NA |
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