| Gene Information | |
|---|---|
| Gene Name | SELP |
| Organism | Homo sapiens (Human) |
| Gene Length | 830 |
| Protein Names | P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P) |
| Target Name | p-selectin |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000174175 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P16109 |
| Gene Card | SELP |
| Uniprot ID | P16109 |
| Pfam | PF00059; PF00084 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999830018) |
| Ortholog in Animals | Alpaca_ SELP ( ortholog_one2one ) Dog_ SELP ( ortholog_one2one ) GuineaPig_ SELP ( ortholog_one2one ) Macaque_ SELP ( ortholog_one2one ) Mouse_ Selp ( ortholog_one2one ) Pig_ SELP ( ortholog_one2one ) Rat_ Selp ( ortholog_one2one ) Rabbit_ SELP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CR1L, SUSD3, F13B, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SELE, SRPX, SVEP1, SEZ6, C8A, CD55, CSMD2, PAPPA2, SUSD6, C4BPA, C9, CR1, PAPPA, SELL, CFB, CD46, C4BPB, CR2, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, SRPX2, C8B, PRF1, SUSD4, C6, C2 |
| Tissue | NA |
| Tissue Specificity | Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1FSB (NMR - ) 1G1Q (X-ray 2.40A ) 1G1R (X-ray 3.40A ) 1G1S (X-ray 1.90A ) 1HES (X-ray 3.00A ) |
| DBSNP | rs3917718 rs6125 rs3917869 rs3917724 rs6124 rs6131 rs6134 rs3917742 rs6130 rs3917769 rs6127 rs2228672 rs3917812 rs6133 rs3917814 rs3917815 rs6136 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:28011641}; Single-pass type I membrane protein {ECO:0000305|PubMed:28011641}. |
| Mouse PG classification | NA |
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