| Gene Information | |
|---|---|
| Gene Name | INPP5F |
| Organism | Homo sapiens (Human) |
| Gene Length | 1132 |
| Protein Names | Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000198825 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y2H2 |
| Gene Card | INPP5F |
| Uniprot ID | Q9Y2H2 |
| Pfam | PF12456; PF02383 |
| In ASD | no |
| Allosteric Prediction | no (-0.279666409) |
| Ortholog in Animals | Alpaca_ INPP5F ( ortholog_one2one ) Dog_ INPP5F ( ortholog_one2one ) GuineaPig_ INPP5F ( ortholog_one2one ) Macaque_ INPP5F ( ortholog_one2one ) Mouse_ Inpp5f ( ortholog_one2one ) Pig_ INPP5F ( ortholog_one2one ) Rat_ Inpp5f ( ortholog_one2one ) Rabbit_ INPP5F ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SH2D1B, SH2D1A, FIG4, INPP5E, SYNJ2, SACM1L, OCRL, INPP5D, INPPL1, INPP5J, SYNJ1, INPP5B, INPP5K |
| Tissue | NA |
| Tissue Specificity | Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138). {ECO:0000269|PubMed:11274189, ECO:0000269|PubMed:26203138}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4XUU (X-ray 2.62A ) |
| DBSNP | rs3736822 rs3188055 |
| Subcellular location [CC] | Membrane, clathrin-coated pit {ECO:0000269|PubMed:25869669}. Early endosome {ECO:0000269|PubMed:25869669}. Recycling endosome {ECO:0000269|PubMed:25869669}. Note=Also found on macropinosomes. {ECO:0000250|UniProtKB:Q8CDA1}. |
| Mouse PG classification | NA |
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