| Gene Information | |
|---|---|
| Gene Name | SEK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 399 |
| Protein Names | Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P45985 |
| Gene Card | MAP2K4 |
| Uniprot ID | P45985 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3ALN (X-ray 2.30A ) 3ALO (X-ray 2.60A ) 3VUT (X-ray 3.50A ) |
| DBSNP | rs17855590 rs1567657403 rs753665559 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Mouse PG classification | NA |
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