| Gene Information | |
|---|---|
| Gene Name | DAPP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 280 |
| Protein Names | Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa) |
| Target Name | dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000070190 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UN19 |
| Gene Card | DAPP1 |
| Uniprot ID | Q9UN19 |
| Pfam | PF00169; PF00017 |
| In ASD | no |
| Allosteric Prediction | no (-0.597470274) |
| Ortholog in Animals | Alpaca_ DAPP1 ( ortholog_one2one ) Dog_ DAPP1 ( ortholog_one2one ) GuineaPig_ DAPP1 ( ortholog_one2one ) Macaque_ DAPP1 ( ortholog_one2one ) Mouse_ Dapp1 ( ortholog_one2one ) Pig_ DAPP1 ( ortholog_one2one ) Rat_ Dapp1 ( ortholog_one2one ) Rabbit_ DAPP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLA, SH2D5, NCK1, GRAP, GRAPL, GRB2, GRAP2, NCK2, SLA2 |
| Tissue | lung, spleen, esophagus.mucosa, lower.leg.skin, suprapubic.skin, vagina |
| Tissue Specificity | Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells. {ECO:0000269|PubMed:10432293}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1FAO (X-ray 1.80A ) 1FB8 (X-ray 2.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10770799}. Membrane {ECO:0000269|PubMed:10770799}; Peripheral membrane protein {ECO:0000269|PubMed:10770799}. Note=Membrane-associated after cell stimulation leading to its translocation. |
| Mouse PG classification | NA |
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