| Gene Information | |
|---|---|
| Gene Name | UNC13D |
| Organism | Homo sapiens (Human) |
| Gene Length | 1090 |
| Protein Names | Protein unc-13 homolog D (Munc13-4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000092929 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q70J99 |
| Gene Card | UNC13D |
| Uniprot ID | Q70J99 |
| Pfam | PF00168; PF06292 |
| In ASD | no |
| Allosteric Prediction | no (-0.280294401) |
| Ortholog in Animals | Alpaca_ UNC13D ( ortholog_one2one ) Dog_ UNC13D ( ortholog_one2one ) GuineaPig_ UNC13D ( ortholog_one2one ) Macaque_ UNC13D ( ortholog_one2one ) Mouse_ Unc13d ( ortholog_one2one ) Pig_ UNC13D ( ortholog_one2one ) Rat_ Unc13d ( ortholog_one2one ) |
| Ohnologs | BAIAP3 |
| Paralogs | BAIAP3 |
| Tissue | lung, placenta, spleen |
| Tissue Specificity | Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells. {ECO:0000269|PubMed:14622600, ECO:0000269|PubMed:15548590}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs9904366 rs17496835 rs1135688 |
| Subcellular location [CC] | Cytoplasm. Membrane; Peripheral membrane protein. Late endosome. Recycling endosome. Lysosome. Note=Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles. |
| Mouse PG classification | HPG |
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