| Gene Information | |
|---|---|
| Gene Name | HCAR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 387 |
| Protein Names | Hydroxycarboxylic acid receptor 3 (G-protein coupled receptor 109B) (G-protein coupled receptor HM74) (G-protein coupled receptor HM74B) (Niacin receptor 2) (Nicotinic acid receptor 2) |
| Target Name | hydroxycarboxylic acid receptor 3 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000255398 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P49019 |
| Gene Card | HCAR3 |
| Uniprot ID | P49019 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.216025944) |
| Ortholog in Animals | Alpaca_ HCAR3 ( ortholog_one2one ) Dog_ HCAR2 ( ortholog_one2many ) Mouse_ Hcar2 ( ortholog_one2many ) Rat_ Hcar2 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | P2RY2, P2RY4, OXGR1, P2RY1, SUCNR1, P2RY6, FFAR3, GPR42, FFAR2, HCAR2, HCAR1, OXER1, GPR31, FFAR1, GPR82 |
| Tissue | spleen, tongue, whole.blood |
| Tissue Specificity | Expression largely restricted to adipose tissue and spleen. {ECO:0000269|PubMed:12522134}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1798192 rs17884481 rs118091133 rs116821988 rs1696351 rs201835480 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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