| Gene Information | |
|---|---|
| Gene Name | SEC61A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 476 |
| Protein Names | Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000058262 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P61619 |
| Gene Card | SEC61A1 |
| Uniprot ID | P61619 |
| Pfam | PF10559; PF00344 |
| In ASD | no |
| Allosteric Prediction | no (-0.610573167) |
| Ortholog in Animals | Alpaca_ SEC61A1 ( ortholog_one2one ) Dog_ SEC61A1 ( ortholog_one2one ) GuineaPig_ SEC61A1 ( ortholog_one2one ) Macaque_ SEC61A1 ( ortholog_one2one ) Mouse_ Sec61a1 ( ortholog_one2one ) Pig_ SEC61A1 ( ortholog_one2one ) Rat_ Sec61a1 ( ortholog_one2one ) Rabbit_ SEC61A1 ( ortholog_one2one ) |
| Ohnologs | SEC61A2 |
| Paralogs | SEC61A2 |
| Tissue | NA |
| Tissue Specificity | Expressed in proximal and distal tubules in kidney (at protein level). {ECO:0000269|PubMed:28782633}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6W6L (EM 3.84A ) |
| DBSNP | rs752745051 rs1553721236 rs879255648 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:27392076, ECO:0000269|PubMed:32814900, ECO:0000269|PubMed:8616892}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes exclusively in granular structures in the endoplasmic reticulum (ER). {ECO:0000269|PubMed:27392076}. |
| Mouse PG classification | NA |
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