Gene Information
Gene NameIARS2
OrganismHomo sapiens (Human)
Gene Length1012
Protein NamesIsoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)
Target Nameisoleucine--trna ligase, mitochondrial
Target TypeNA
Gene Age1488 ( ENSG00000067704 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ9NSE4
Gene CardIARS2
Uniprot IDQ9NSE4
PfamPF08264; PF00133; PF06827
In ASDno
Allosteric Predictionyes (0.510888952)
Ortholog in AnimalsAlpaca_ IARS2 ( ortholog_one2one )
Dog_ IARS2 ( ortholog_one2one )
GuineaPig_ IARS2 ( ortholog_one2one )
Macaque_ IARS2 ( ortholog_one2one )
Mouse_ Iars2 ( ortholog_one2one )
Pig_ IARS2 ( ortholog_one2one )
Rat_ Iars2 ( ortholog_one2one )
Rabbit_ IARS2 ( ortholog_one2one )
OhnologsNA
ParalogsVARS1, MARS2, MARS1, LARS2, IARS1, VARS2, LARS1
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs2577154  rs1428331445  rs1571845061  rs11800305  rs143722284  rs1571863769  rs532672867  rs146618526  rs199840959  rs151241066  rs587783070  rs1571865562 
Subcellular location [CC]Mitochondrion matrix {ECO:0000250}.
Mouse PG classificationNA
click here to return to the previous page