| Gene Information | |
|---|---|
| Gene Name | TTC28 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2481 |
| Protein Names | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000100154 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q96AY4 |
| Gene Card | TTC28 |
| Uniprot ID | Q96AY4 |
| Pfam | PF12770; PF13176 |
| In ASD | no |
| Allosteric Prediction | no (-1.207570723) |
| Ortholog in Animals | Alpaca_ TTC28 ( ortholog_one2one ) Dog_ TTC28 ( ortholog_one2one ) GuineaPig_ TTC28 ( ortholog_one2one ) Macaque_ TTC28 ( ortholog_one2one ) Mouse_ Ttc28 ( ortholog_one2one ) Pig_ TTC28 ( ortholog_one2one ) Rat_ Ttc28 ( ortholog_one2one ) Rabbit_ TTC28 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GPSM1, GPSM2, RAPSN, GPSM3, TTC24, TTC29 |
| Tissue | NA |
| Tissue Specificity | Widely expressed in fetal tissues. In adult tissues, expressed in testis and ovary and, at much lower levels, in kidney and pancreas. {ECO:0000269|PubMed:23036704}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Midbody {ECO:0000250}. Note=At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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