| Gene Information | |
|---|---|
| Gene Name | SEC22B |
| Organism | Homo sapiens (Human) |
| Gene Length | 215 |
| Protein Names | Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000265808 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75396 |
| Gene Card | SEC22B |
| Uniprot ID | O75396 |
| Pfam | PF13774; PF00957 |
| In ASD | no |
| Allosteric Prediction | no (-0.537740449) |
| Ortholog in Animals | GuineaPig_ SEC22B ( ortholog_one2one ) Macaque_ SEC22B ( ortholog_one2one ) Mouse_ Sec22b ( ortholog_one2one ) Pig_ SEC22B ( ortholog_one2one ) Rat_ Sec22b ( ortholog_one2one ) Rabbit_ SEC22B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VAMP8, VAMP2, SEC22A, VAMP7, VAMP3, VAMP4, VAMP1, SEC22C, VAMP5, YKT6 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.102095(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2NUP (X-ray 2.80A ) 2NUT (X-ray 2.30A ) 3EGD (X-ray 2.70A ) 3EGX (X-ray 3.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q4KM74}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q4KM74}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q4KM74}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q4KM74}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q4KM74}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000250|UniProtKB:Q4KM74, ECO:0000269|PubMed:17081065}. |
| Mouse PG classification | NA |
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