| Gene Information | |
|---|---|
| Gene Name | CHSY1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 802 |
| Protein Names | Chondroitin sulfate synthase 1 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 1) (Chondroitin synthase 1) (ChSy-1) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1) (N-acetylgalactosaminyltransferase 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000131873 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q86X52 |
| Gene Card | CHSY1 |
| Uniprot ID | Q86X52 |
| Pfam | PF05679 |
| In ASD | no |
| Allosteric Prediction | no (-1.35628582) |
| Ortholog in Animals | Dog_ CHSY1 ( ortholog_one2one ) GuineaPig_ CHSY1 ( ortholog_one2one ) Macaque_ CHSY1 ( ortholog_one2one ) Mouse_ Chsy1 ( ortholog_one2one ) Pig_ CHSY1 ( ortholog_one2one ) Rat_ Chsy1 ( ortholog_one2one ) Rabbit_ CHSY1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CHSY3, CHPF, CHPF2, B4GALNT3, B4GALNT4, CSGALNACT2, CSGALNACT1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous, with the highest levels in placenta. Detected at low levels in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, adrenal gland, mammary gland, stomach, small intestine, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:11514575, ECO:0000269|PubMed:12907687}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3743193 rs387906985 rs4426333 |
| Subcellular location [CC] | Golgi apparatus, Golgi stack membrane {ECO:0000305|PubMed:11514575}; Single-pass type II membrane protein {ECO:0000305|PubMed:11514575}. Secreted {ECO:0000269|PubMed:21129727}. |
| Mouse PG classification | HPG |
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