| Gene Information | |
|---|---|
| Gene Name | SEC31A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1220 |
| Protein Names | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000138674 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O94979 |
| Gene Card | SEC31A |
| Uniprot ID | O94979 |
| Pfam | PF12931 |
| In ASD | no |
| Allosteric Prediction | no (-0.6387036) |
| Ortholog in Animals | Alpaca_ SEC31A ( ortholog_one2one ) Dog_ SEC31A ( ortholog_one2one ) GuineaPig_ SEC31A ( ortholog_one2one ) Macaque_ SEC31A ( ortholog_one2one ) Mouse_ Sec31a ( ortholog_one2one ) Pig_ SEC31A ( ortholog_one2one ) Rat_ Sec31a ( ortholog_one2one ) Rabbit_ SEC31A ( ortholog_one2one ) |
| Ohnologs | SEC31B |
| Paralogs | SEC31B |
| Tissue | NA |
| Tissue Specificity | Abundantly and ubiquitously expressed. {ECO:0000269|PubMed:10574704, ECO:0000269|PubMed:10788476}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.036082(Mouse);0.095305(Rat);0.061488(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3WXA (X-ray 2.36A ) 7SUL (X-ray 2.40A ) |
| DBSNP | rs34554214 rs3797036 rs35579207 rs35739017 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:10788476, ECO:0000269|PubMed:16957052, ECO:0000269|PubMed:22358839, ECO:0000269|PubMed:27716508}; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:17428803}. Note=Associates with membranes in a GTP-dependent manner (By similarity). Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:25201882, PubMed:28442536, PubMed:17428803). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:28442536}. |
| Mouse PG classification | NA |
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