| Gene Information | |
|---|---|
| Gene Name | TRPC6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 931 |
| Protein Names | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000137672 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9Y210 |
| Gene Card | TRPC6 |
| Uniprot ID | Q9Y210 |
| Pfam | PF12796; PF00520; PF08344 |
| In ASD | yes |
| Allosteric Prediction | yes (0.901735344) |
| Ortholog in Animals | Alpaca_ TRPC6 ( ortholog_one2one ) Dog_ TRPC6 ( ortholog_one2one ) GuineaPig_ TRPC6 ( ortholog_one2one ) Macaque_ TRPC6 ( ortholog_one2one ) Mouse_ Trpc6 ( ortholog_one2one ) Pig_ TRPC6 ( ortholog_one2one ) Rabbit_ TRPC6 ( ortholog_one2one ) |
| Ohnologs | TRPC3 |
| Paralogs | TRPC7, TRPC3, TRPC1, TRPC5, TRPC4 |
| Tissue | lung, placenta, thyroid |
| Tissue Specificity | Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. {ECO:0000269|PubMed:15924139}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5YX9 (EM 3.80A ) 6UZ8 (EM 2.84A ) 6UZA (EM 3.08A ) 7A6U (EM 3.62A ) 7DXF (EM 2.90A ) 7DXG (EM 2.90A ) |
| DBSNP | rs3802829 rs121434390 rs146776939 rs121434391 rs35857503 rs1451194842 rs779430565 rs121434392 rs777715086 rs36111323 rs771594597 rs121434394 rs121434395 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | LPG |
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