| Gene Information | |
|---|---|
| Gene Name | SEPT12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 358 |
| Protein Names | Septin-12 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8IYM1 |
| Gene Card | SEPTIN12 |
| Uniprot ID | Q8IYM1 |
| Pfam | PF00735 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in lymph node. {ECO:0000269|PubMed:15915442, ECO:0000269|PubMed:17967425}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.255181(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6MQ9 (X-ray 1.86A ) 6MQB (X-ray 2.12A ) 6MQK (X-ray 2.19A ) 6MQL (X-ray 2.17A ) |
| DBSNP | rs199696526 rs371195126 rs6500633 |
| Subcellular location [CC] | Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18047794}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18047794}. Nucleus {ECO:0000269|PubMed:25775403}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:22275165}. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the central spindle region and to the midbody during cytokinesis. Found in the sperm annulus. Colocalized with SPAG4 at the nuclear periphery in round spermatids, at sperm neck in elongated spermatids and at midpiece regions in ejaculated spermatozoa. {ECO:0000269|PubMed:18047794, ECO:0000269|PubMed:20801438, ECO:0000269|PubMed:22275165, ECO:0000269|PubMed:25775403}. |
| Mouse PG classification | NA |
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