| Gene Information | |
|---|---|
| Gene Name | TBXAS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 533 |
| Protein Names | Thromboxane-A synthase (TXA synthase) (TXS) (EC 5.3.99.5) (Cytochrome P450 5A1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) |
| Target Name | thromboxane-a synthase |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000059377 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P24557 |
| Gene Card | TBXAS1 |
| Uniprot ID | P24557 |
| Pfam | PF00067 |
| In ASD | no |
| Allosteric Prediction | yes (0.761969074) |
| Ortholog in Animals | Alpaca_ TBXAS1 ( ortholog_one2one ) Dog_ TBXAS1 ( ortholog_one2one ) GuineaPig_ TBXAS1 ( ortholog_one2one ) Macaque_ TBXAS1 ( ortholog_one2one ) Mouse_ Tbxas1 ( ortholog_one2one ) Pig_ TBXAS1 ( ortholog_one2one ) Rat_ Tbxas1 ( ortholog_one2one ) Rabbit_ TBXAS1 ( ortholog_one2one ) |
| Ohnologs | CYP3A5, CYP3A4 |
| Paralogs | NA |
| Tissue | spleen, whole.blood |
| Tissue Specificity | Platelets, lung, kidney, spleen, macrophages and lung fibroblasts. {ECO:0000269|PubMed:1714723, ECO:0000269|PubMed:7925341}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs6138 rs13306050 rs4529 rs140005285 rs1016604233 rs8192833 rs5768 rs6137 rs55856189 rs5769 rs5770 rs5771 rs6140 rs4529 rs4529 rs3735354 rs3735354 rs5760 rs199422117 rs4528 rs5762 rs4526 rs8192868 rs5763 rs41311778 rs199422116 rs199422114 rs8192864 rs13306050 rs13306050 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:8366093}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |