| Gene Information | |
|---|---|
| Gene Name | TP53BP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1972 |
| Protein Names | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000067369 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q12888 |
| Gene Card | TP53BP1 |
| Uniprot ID | Q12888 |
| Pfam | PF09038 |
| In ASD | no |
| Allosteric Prediction | no (-0.393237095) |
| Ortholog in Animals | Alpaca_ TP53BP1 ( ortholog_one2one ) Dog_ TP53BP1 ( ortholog_one2one ) Macaque_ TP53BP1 ( ortholog_one2one ) Mouse_ Trp53bp1 ( ortholog_one2one ) Pig_ TP53BP1 ( ortholog_one2one ) Rat_ Tp53bp1 ( ortholog_one2one ) Rabbit_ TP53BP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.063290(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GZH (X-ray 2.60A ) 1KZY (X-ray 2.50A ) 1XNI (X-ray 2.80A ) 2G3R (X-ray 1.25A ) 2IG0 (X-ray 1.70A ) 2LVM (NMR - ) 2MWO (NMR - ) 2MWP (NMR - ) 3LGF (X-ray 1.50A ) 3LGL (X-ray 1.60A ) 3LH0 (X-ray 1.90A ) 4CRI (X-ray 2.35A ) 4RG2 (X-ray 1.50A ) 4X34 (X-ray 1.80A ) 5ECG (X-ray 3.00A ) 5J26 (X-ray 2.50A ) 5KGF (EM 4.54A ) 5Z78 (X-ray 1.76A ) 5ZCJ (X-ray 2.00A ) 6CO1 (X-ray 2.18A ) 6CO2 (X-ray 2.49A ) 6IU7 (X-ray 1.90A ) 6IUA (X-ray 1.70A ) 6MXX (X-ray 2.30A ) 6MXY (X-ray 1.62A ) 6MXZ (X-ray 2.50A ) 6MY0 (X-ray 2.20A ) 6RML (X-ray 2.81A ) 6RMM (X-ray 3.53A ) 6UPT (X-ray 1.96A ) 6VA5 (X-ray 1.28A ) 6VIP (X-ray 1.36A ) 7LIN (X-ray 1.44A ) 7LIO (X-ray 3.01A ) |
| DBSNP | rs560191 rs689647 rs45443496 rs34823068 rs34185035 rs45470395 rs45482998 rs2602141 rs34740611 rs45500399 rs3803339 rs2230449 rs11554564 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11331310, ECO:0000269|PubMed:15525939, ECO:0000269|PubMed:16294045, ECO:0000269|PubMed:16294047, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:19176521, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:9748285}. Chromosome {ECO:0000269|PubMed:12824158, ECO:0000269|PubMed:15525939, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:24703952, ECO:0000269|PubMed:28241136}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P70399}. Note=Localizes to the nucleus in absence of DNA damage (PubMed:28241136). Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600). Associated with kinetochores during mitosis (By similarity). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:28241136}. |
| Mouse PG classification | NA |
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