| Gene Information | |
|---|---|
| Gene Name | SDK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2213 |
| Protein Names | Protein sidekick-1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000146555 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7Z5N4 |
| Gene Card | SDK1 |
| Uniprot ID | Q7Z5N4 |
| Pfam | PF00041; PF07679 |
| In ASD | no |
| Allosteric Prediction | no (-0.845891113) |
| Ortholog in Animals | Alpaca_ SDK1 ( ortholog_one2one ) Dog_ SDK1 ( ortholog_one2one ) GuineaPig_ SDK1 ( ortholog_one2one ) Macaque_ SDK1 ( ortholog_one2one ) Mouse_ Sdk1 ( ortholog_one2one ) Pig_ SDK1 ( ortholog_one2one ) Rat_ Sdk1 ( ortholog_one2one ) |
| Ohnologs | CNTN1, SDK2 |
| Paralogs | CNTN5, CNTN2, NFASC, ROBO2, SDK2, CNTN3, HMCN2, CNTN6, DSCAML1, VSIG10L, CNTN1, IGDCC4, IGSF21, VCAM1, ROBO1, L1CAM, BOC, DCC, IGDCC3, ROBO4, IGSF9, VSIG10, DSCAM, CDON, NCAM1, ROBO3, CHL1, NRCAM, NEO1, IGSF9B, MXRA5, IGSF10, PTPRQ, NCAM2, PRTG, CNTN4 |
| Tissue | brain |
| Tissue Specificity | Up-regulated in glomeruli in HIV-associated nephropathy. In diseased glomeruli, significantly overexpressed and the expression is no longer restricted to mesangial cells but includes podocytes and parietal epithelial cells (PubMed:15213259). {ECO:0000269|PubMed:15213259}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11978101 rs671694 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q8AV58}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8AV58}. Synapse {ECO:0000250|UniProtKB:Q8AV58}. |
| Mouse PG classification | NA |
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