| Gene Information | |
|---|---|
| Gene Name | RXFP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 757 |
| Protein Names | Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1) |
| Target Name | relaxin receptor 1 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000171509 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9HBX9 |
| Gene Card | RXFP1 |
| Uniprot ID | Q9HBX9 |
| Pfam | PF00001; PF00057; PF13855 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000347196) |
| Ortholog in Animals | Alpaca_ RXFP1 ( ortholog_one2one ) Dog_ RXFP1 ( ortholog_one2one ) GuineaPig_ Rxfp1 ( ortholog_one2one ) Macaque_ RXFP1 ( ortholog_one2one ) Mouse_ Rxfp1 ( ortholog_one2one ) Pig_ RXFP1 ( ortholog_one2one ) Rat_ Rxfp1 ( ortholog_one2one ) Rabbit_ RXFP1 ( ortholog_one2one ) |
| Ohnologs | RXFP2, TSHR |
| Paralogs | CD180, TLR8, NRROS, TLR5, TSKU, TLR7, TLR10, RXFP2, TLR6, LRRC3B, IGFALS, TLR3, TLR2, TLR4, LRRC17, LRRC32, LRRC53, VASN, TLR1, LRRC3C, LRRC3, LRIT2 |
| Tissue | brain, endometrium |
| Tissue Specificity | Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen. {ECO:0000269|PubMed:16051677}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2JM4 (NMR - ) 2M7P (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16051677}; Multi-pass membrane protein {ECO:0000269|PubMed:16051677}. |
| Mouse PG classification | NA |
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