Gene Information
Gene NameCNGA3
OrganismHomo sapiens (Human)
Gene Length694
Protein NamesCyclic nucleotide-gated cation channel alpha-3 (Cone photoreceptor cGMP-gated channel subunit alpha) (Cyclic nucleotide-gated channel alpha-3) (CNG channel alpha-3) (CNG-3) (CNG3)
Target Namecyclic nucleotide-gated channel alpha-3
Target TypeClinical trial target
Gene Age886 ( ENSG00000144191 )
Evolutionary StageEukaryota
AlphaFoldDBQ16281
Gene CardCNGA3
Uniprot IDQ16281
PfamPF16526; PF00027; PF00520
In ASDno
Allosteric Predictionyes (0.193435501)
Ortholog in AnimalsAlpaca_ CNGA3 ( ortholog_one2one )
Dog_ CNGA3 ( ortholog_one2one )
GuineaPig_ CNGA3 ( ortholog_one2one )
Macaque_ CNGA3 ( ortholog_one2one )
Mouse_ Cnga3 ( ortholog_one2one )
Pig_ CNGA3 ( ortholog_one2one )
Rat_ Cnga3 ( ortholog_one2one )
Rabbit_ CNGA3 ( ortholog_one2one )
OhnologsCNGA2, CNGA1
ParalogsKCNH7, KCNH1, HCN3, KCNH3, HCN4, HCN2, KCNH8, HCN1, CNGB3, CNGB1, CNGA1, KCNH6, KCNH2, KCNH4, CNGA2, CNGA4, KCNH5
TissueNA
Tissue SpecificityProminently expressed in retina.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3SWY  (X-ray  1.90A  )  7RHS  (EM  2.93A  ) 
DBSNP rs62156348  rs199859850  rs34314205  rs747447519  rs104893612  rs762773298  rs761554853  rs2271041  rs762668060  rs138958917  rs147415641  rs148616345  rs374258471  rs943314733  rs781673067  rs104893620  rs778114016  rs763421555  rs104893614  rs104893613  rs104893616  rs1227761587  rs766637612  rs1464167194  rs916035276  rs1553450734  rs137852608  rs141386891  rs767083685  rs104893621  rs749842881  rs117522010  rs373954146  rs908111816  rs104893619  rs775332304  rs104893617  rs781227859  rs104893615  rs552069173  rs201747279  rs201782746  rs763041373  rs774676415  rs141577844 
Subcellular location [CC]Membrane;
Multi-pass membrane protein.
Mouse PG classificationHPG
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