Gene Information
Gene NameOGA
OrganismHomo sapiens (Human)
Gene Length916
Protein NamesProtein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000198408 )
Evolutionary StageEuk+Bac
AlphaFoldDBO60502
Gene CardOGA
Uniprot IDO60502
PfamPF07555
In ASDno
Allosteric Predictionyes (0.390892904)
Ortholog in AnimalsAlpaca_ OGA ( ortholog_one2one )
Dog_ OGA ( ortholog_one2one )
GuineaPig_ OGA ( ortholog_one2one )
Macaque_ OGA ( ortholog_one2one )
Mouse_ Oga ( ortholog_one2one )
Pig_ OGA ( ortholog_one2one )
Rat_ Oga ( ortholog_one2one )
Rabbit_ OGA ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityUbiquitous. Shows highest expression in the brain, placenta and pancreas. {ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11341771}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2YDQ  (X-ray  2.60A  )  5M7R  (X-ray  2.35A  )  5M7S  (X-ray  2.40A  )  5M7T  (X-ray  2.60A  )  5M7U  (X-ray  2.30A  )  5TKE  (X-ray  2.48A  )  5UHK  (X-ray  2.97A  )  5UHL  (X-ray  3.14A  )  5UHO  (X-ray  3.21A  )  5UHP  (X-ray  2.79A  )  5UN8  (X-ray  2.13A  )  5UN9  (X-ray  2.50A  )  5VVO  (X-ray  2.60A  )  5VVT  (X-ray  2.80A  )  5VVU  (X-ray  2.70A  )  5VVV  (X-ray  2.80A  )  5VVX  (X-ray  2.90A  )  6HKI  (X-ray  3.30A  )  6PM9  (X-ray  2.86A  )  7OU6  (X-ray  2.41A  ) 
DBSNP rs3740421  rs17853930 
Subcellular location [CC][Isoform 3]: Nucleus {ECO:0000269|PubMed:11341771}.;
[Isoform 1]: Cytoplasm {ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11341771, ECO:0000269|PubMed:11788610}.
Mouse PG classificationNA
click here to return to the previous page