| Gene Information | |
|---|---|
| Gene Name | CD164 |
| Organism | Homo sapiens (Human) |
| Gene Length | 197 |
| Protein Names | Sialomucin core protein 24 (MUC-24) (Endolyn) (Multi-glycosylated core protein 24) (MGC-24) (MGC-24v) (CD antigen CD164) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000135535 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q04900 |
| Gene Card | CD164 |
| Uniprot ID | Q04900 |
| Pfam | PF05283 |
| In ASD | no |
| Allosteric Prediction | no (-1.050521652) |
| Ortholog in Animals | Alpaca_ CD164 ( ortholog_one2one ) Dog_ CD164 ( ortholog_one2one ) GuineaPig_ CD164 ( ortholog_one2one ) Macaque_ CD164 ( ortholog_one2one ) Mouse_ Cd164 ( ortholog_one2one ) Pig_ CD164 ( ortholog_one2one ) Rat_ Cd164 ( ortholog_one2one ) Rabbit_ CD164 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CD164L2, TMEM123 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells. {ECO:0000269|PubMed:10878358, ECO:0000269|PubMed:11027692, ECO:0000269|PubMed:1478919, ECO:0000269|PubMed:16859559, ECO:0000269|PubMed:9763543}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Lysosome membrane {ECO:0000269|PubMed:11027692}; Single-pass type I membrane protein {ECO:0000269|PubMed:11027692}. Endosome membrane {ECO:0000269|PubMed:11027692}; Single-pass type I membrane protein {ECO:0000269|PubMed:11027692}. Cell membrane {ECO:0000269|PubMed:11027692, ECO:0000269|PubMed:26197441}; Single-pass type I membrane protein {ECO:0000269|PubMed:11027692}.; [Isoform 2]: Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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