| Gene Information | |
|---|---|
| Gene Name | TWF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 349 |
| Protein Names | Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000247596 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6IBS0 |
| Gene Card | TWF2 |
| Uniprot ID | Q6IBS0 |
| Pfam | PF00241 |
| In ASD | no |
| Allosteric Prediction | no (-0.292583051) |
| Ortholog in Animals | Alpaca_ TWF2 ( ortholog_one2one ) Dog_ TWF2 ( ortholog_one2one ) GuineaPig_ TWF2 ( ortholog_one2one ) Macaque_ TWF2 ( ortholog_one2one ) Mouse_ Twf2 ( ortholog_one2one ) Pig_ TWF2 ( ortholog_one2one ) Rat_ Twf2 ( ortholog_one2many ) Rabbit_ TWF2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TWF1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed (at protein level). {ECO:0000269|PubMed:10406962}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2VAC (X-ray 1.70A ) 2W0I (X-ray 1.80A ) |
| DBSNP | rs35114109 rs35711542 rs867679383 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10406962}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10406962}. Cell projection, stereocilium {ECO:0000250}. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization. |
| Mouse PG classification | NA |
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