| Gene Information | |
|---|---|
| Gene Name | SDCBP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 292 |
| Protein Names | Syntenin-2 (Similar to TACIP18) (SITAC) (Syndecan-binding protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000125775 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9H190 |
| Gene Card | SDCBP2 |
| Uniprot ID | Q9H190 |
| Pfam | PF00595 |
| In ASD | no |
| Allosteric Prediction | no (-1.42923441) |
| Ortholog in Animals | Alpaca_ SDCBP2 ( ortholog_one2one ) Dog_ SDCBP2 ( ortholog_one2one ) GuineaPig_ SDCBP2 ( ortholog_one2one ) Macaque_ SDCBP2 ( ortholog_one2one ) Mouse_ Sdcbp2 ( ortholog_one2one ) Pig_ SDCBP2 ( ortholog_one2one ) Rat_ Sdcbp2 ( ortholog_one2one ) Rabbit_ SDCBP2 ( ortholog_one2one ) |
| Ohnologs | SDCBP |
| Paralogs | SDCBP, APBA1, APBA2, APBA3 |
| Tissue | small.intestine |
| Tissue Specificity | Preferentially expressed in cells of the digestive tract (PubMed:11102519). Low expression in skeletal muscle and kidney (PubMed:11102519). Detected in differentiated keratinocytes of normal and malignant epithelium (PubMed:22623796). In healthy skin, expression is localized in suprabasal epidermal layers (PubMed:22623796). {ECO:0000269|PubMed:11102519, ECO:0000269|PubMed:22623796}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2273959 rs35367003 rs1048621 rs4814111 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15961997}. Nucleus, nucleolus {ECO:0000269|PubMed:15961997, ECO:0000269|PubMed:23300061}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23300061}. Cell membrane {ECO:0000269|PubMed:15961997}. Nucleus speckle {ECO:0000269|PubMed:15961997}. Note=Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519). Colocalizes with TM4SF1 in the apical region of the cell (PubMed:11102519). Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments (PubMed:15961997). PIP2 plays an important role in the distribution of SDCBP2 (PubMed:23300061). {ECO:0000269|PubMed:11102519, ECO:0000269|PubMed:15961997, ECO:0000269|PubMed:23300061}. |
| Mouse PG classification | NA |
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