Gene Information
Gene NameMYH14
OrganismHomo sapiens (Human)
Gene Length1995
Protein NamesMyosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C)
Target Namemyosin-14
Target TypeNA
Gene Age382 ( ENSG00000105357 )
Evolutionary StageEukaryota
AlphaFoldDBQ7Z406
Gene CardMYH14
Uniprot IDQ7Z406
PfamPF00063; PF02736; PF01576
In ASDno
Allosteric Predictionyes (0.722275953)
Ortholog in AnimalsAlpaca_ MYH14 ( ortholog_one2one )
Dog_ MYH14 ( ortholog_one2one )
GuineaPig_ MYH14 ( ortholog_one2one )
Macaque_ MYH14 ( ortholog_one2one )
Mouse_ Myh14 ( ortholog_one2one )
Pig_ MYH14 ( ortholog_one2one )
Rat_ Myh14 ( ortholog_one2one )
OhnologsMYH9, MYH11
ParalogsMYO3A, MYH10, TMF1, MYO7B, MYO1D, CCDC102B, MYH1, MYO19, MYO1C, MYH3, MYH7, MYO1A, MYO15A, MYH9, MYO18A, MYO1E, MYH2, MYH15, MYO3B, CCDC102A, MYO5A, MYO1G, MYO1H, MYO18B, MYO5C, MYO9B, MYO7A, MYH7B, MYO5B, CGNL1, CGN, MYH11, MYO16, MYO10, MYH8, MYH6, MYO9A, MYO6, MYH4, CCDC158, MYO1B, MYO1F, MYH13
TissueNA
Tissue SpecificityHigh levels of expression are found in brain (highest in corpus callosum), heart, kidney, liver, lung, small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No detectable expression is found in thymus, spleen, placenta and lymphocytes. {ECO:0000269|PubMed:12909352, ECO:0000269|PubMed:14594953, ECO:0000269|PubMed:19240025}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5I4E  (X-ray  2.25A  )  5JLH  (EM  3.90A  ) 
DBSNP rs119103281  rs200424400  rs34498817  rs119103280  rs28940307  rs113993956  rs28940306  rs910420638  rs11669191  rs680446  rs769482601 
Subcellular location [CC]NA
Mouse PG classificationNA
click here to return to the previous page