Gene Information
Gene NameIL37
OrganismHomo sapiens (Human)
Gene Length218
Protein NamesInterleukin-37 (IL-37) (FIL1 zeta) (IL-1X) (Interleukin-1 family member 7) (IL-1F7) (Interleukin-1 homolog 4) (IL-1H) (IL-1H4) (Interleukin-1 zeta) (IL-1 zeta) (Interleukin-1-related protein) (IL-1RP1)
Target Nameinterleukin-37
Target TypeSuccessful target
Gene Age93 ( ENSG00000125571 )
Evolutionary StageVertebrata
AlphaFoldDBQ9NZH6
Gene CardIL37
Uniprot IDQ9NZH6
PfamPF00340
In ASDno
Allosteric Predictionno (-0.360907464)
Ortholog in AnimalsDog_ IL37 ( ortholog_one2one )
Macaque_ IL37 ( ortholog_one2one )
OhnologsNA
ParalogsIL36G, IL36A, IL36B, IL1F10, IL1RN, IL36RN, IL1B
Tissueskin, lower.leg.skin, suprapubic.skin
Tissue SpecificityIn general, low constitutive expression, if any, in healthy tissues;
high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart. {ECO:0000269|PubMed:11145836, ECO:0000269|PubMed:20935647}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5HN1  (X-ray  2.25A  )  6NCU  (X-ray  3.50A  ) 
DBSNP rs3811046  rs3811047  rs2708943  rs2723183  rs2723187  rs28947200  rs2708947  rs2723192 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647}. Nucleus {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647, ECO:0000269|PubMed:33674380}. Secreted {ECO:0000269|PubMed:11145836, ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33674380}. Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647, PubMed:33674380). Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10;
it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059, PubMed:33674380). {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33674380}.
Mouse PG classificationNA
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