| Gene Information | |
|---|---|
| Gene Name | RTN3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1032 |
| Protein Names | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000133318 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | O95197 |
| Gene Card | RTN3 |
| Uniprot ID | O95197 |
| Pfam | PF02453 |
| In ASD | no |
| Allosteric Prediction | no (-0.707209487) |
| Ortholog in Animals | Alpaca_ RTN3 ( ortholog_one2one ) Alpaca_ RTN3 ( ortholog_one2many ) Dog_ RTN3 ( ortholog_one2many ) Macaque_ RTN3 ( ortholog_one2one ) Mouse_ Rtn3 ( ortholog_one2one ) Rat_ Rtn3 ( ortholog_one2one ) Rabbit_ RTN3 ( ortholog_one2one ) |
| Ohnologs | RTN4 |
| Paralogs | PRR18, RTN4, RTN1, RTN2 |
| Tissue | NA |
| Tissue Specificity | Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma. {ECO:0000269|PubMed:10331947, ECO:0000269|PubMed:12811824, ECO:0000269|PubMed:14986927, ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:15946766}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7BRU (X-ray 2.15A ) |
| DBSNP | rs11551944 rs7936660 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12811824, ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:16979658, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17182608, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:29117567, ECO:0000269|PubMed:34313226}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:16979658, ECO:0000269|PubMed:29117567}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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